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  • Title: Rheoencephalographic and electroencephalographic studies on nicergoline.
    Author: Dikova M, Tsikalova R, Nikolov R, Nikolova M, Patroneva A.
    Journal: Methods Find Exp Clin Pharmacol; 1990 Jun; 12(5):309-13. PubMed ID: 2232965.
    Abstract:
    The effect of nicergoline on the rheoencephalogram (REG) and on spontaneous electroencephalographic activity (EEG) was studied in acute experiments in cats. The following REG parameters were assayed: amplitude, anacrotic section of the curve and its relative part and dicrotic index. EEG spectra were derived from 10-sec samples of ECoG and the relative amplitude was estimated at 2 Hz-intervals from 0-44 Hz. The REG study showed that nicergoline (0.05 mg/kg i.v.) caused an increase of the amplitude, and a decrease of the anacrote, of the relative part of the anacrote and the dicrotic index - changes indicating a lowering of cerebrovascular resistance. EEG study showed a decrease of the slow activities (theta and delta), and an increase of the fast activities (alpha and beta-1).
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