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  • Title: Evidence that the kinesin light chain domain contains tetratricopeptide repeat units.
    Author: Fisher SQ, Weck M, Landers JE, Emrich J, Middleton SA, Cox J, Gentile L, Parish CA.
    Journal: J Struct Biol; 2012 Mar; 177(3):602-12. PubMed ID: 22330276.
    Abstract:
    Homology models were built for various length sequences of the kinesin-1 light chain (KLC) domain of Drosophila melanogaster and subjected to 200 ns of all-atom molecular dynamics. We also cloned, expressed and characterized these regions spectroscopically. Results confirm that KLC contains tetratricopeptide repeat units; a regular array of repeating 34-residue helix-loop-helix monomers. Experimental and computational evidence is provided confirming the stability and overall helicity of individual TPR repeats as well as individual TPR units incorporated into a multi-TPR structure.
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