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  • Title: Electrochemical sensor for guanine using a self-assembled monolayer of 1,8,15,22-tetraaminophthalocyanatonickel(II) on glassy carbon electrode.
    Author: Jeevagan AJ, John SA.
    Journal: Anal Biochem; 2012 May 01; 424(1):21-6. PubMed ID: 22330605.
    Abstract:
    This article describes the selective determination of guanine (G) using the self-assembled monolayer (SAM) of 1,8,15,22-tetraaminophthalocyanatonickel(II) (4α-Ni(II)TAPc) modified glassy carbon electrode (GCE) in 0.2 M acetate buffer solution (pH 4.0). The SAM of 4α-Ni(II)TAPc was formed on GCE by spontaneous adsorption of 1 mM 4α-Ni(II)TAPc in dimethylformamide (DMF). It shows two pairs of redox waves corresponding to Ni(III)/Ni(II) and Ni(III)Pc(-1)/Ni(III)Pc(-2) in 0.2 M acetate buffer solution. The SAM modified electrode exhibits excellent electrocatalytic activity toward the oxidation of G by enhancing its oxidation current with 150 mV less positive potential shift in contrast to bare GCE. Furthermore, the SAM modified electrode selectively determines G in the presence of high concentration of adenine (A). In differential pulse voltammetry measurements, the oxidation current response of G was increased linearly in the concentration range of 10 to 100 μM, and a detection limit was found to be 3×10(-8)M (signal/noise=3).
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