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  • Title: [The progress in expression of genes of the oligodendrocyte lineage-myelin basic protein in oral lichen planus].
    Author: Zeng J, Xu J, Fan Y.
    Journal: Hua Xi Kou Qiang Yi Xue Za Zhi; 2011 Dec; 29(6):576-9. PubMed ID: 22332565.
    Abstract:
    OBJECTIVE: The aim of this study was to determine the expression of genes of the oligodendrocyte lineage-myelin basic protein (Golli-MBP) in peripheral blood mononuclear cell (PBMC) in oral lichen planus (OLP) and to further understand the pathogenesis of OLP. METHODS: PBMC was obtained by density gradient centrifugation, and the expression of Golli-MBP in PBMC was investigated in erythematous/erosive OLP (20 cases), reticular OLP (16 cases) and normal controls (19 cases) using reverse transcription-polymerase chain reaction (RT-PCR) and Western blot methods. RESULTS: RT-PCR results showed that Golli-MBP mRNA was overexpressed in erythematous/erosive and reticular OLP as compared with normal control group (P < 0.01). Western blot assay indicated that erythematous/erosive and reticular OLP patients had a higher expression level of Golli-MBP protein in PBMC than normal controls (P < 0.01). However, there were no significant differences between erythematous/erosive and reticular groups in Golli-MBP mRNA and protein expression (P > 0.05). CONCLUSION: The data accumulated here strongly indicate that Golli-MBP was involved in the pathogenesis of OLP.
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