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  • Title: A highly selective and sensitive in vivo fluorosensor for zinc(II) without cytotoxicity.
    Author: Mistri T, Dolai M, Chakraborty D, Khuda-Bukhsh AR, Das KK, Ali M.
    Journal: Org Biomol Chem; 2012 Mar 28; 10(12):2380-4. PubMed ID: 22334308.
    Abstract:
    A highly selective and sensitive fluorescent Zn(2+) sensor, 2,6-bis(2-hydroxy-benzoic acid hydrazide)-4-methylphenol (1), was designed and synthesized. In aqueous THF (4 : 6 v/v) ligand 1 induces a 2 : 1 complex formation with respect to Zn(2+) at physiological pH. This probe features visible light excitation(390 nm) and emission (490 nm) profiles, excellent selectivity responses for Zn(2+)over other competing biological metal ions with K(d) < 1 pM(2), LOD < 1 ng L(-1) and about 680 fold enhancement in fluorescent intensity upon Zn(2+) binding. It also exhibits cell permeability and intracellular Zn(2+) sensing in A375 human melanoma cancer cell.
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