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  • Title: Body mass index kinetics and risk factors of malnutrition one year after radical oesophagectomy for cancer.
    Author: Ouattara M, D'Journo XB, Loundou A, Trousse D, Dahan L, Doddoli C, Seitz JF, Thomas PA.
    Journal: Eur J Cardiothorac Surg; 2012 May; 41(5):1088-93. PubMed ID: 22334635.
    Abstract:
    OBJECTIVE: Malnutrition is common after oesophageal cancer surgery. This study aims to investigate body mass index (BMI) kinetics and the risk factors of malnutrition among 1-year disease-free survivors after radical transthoracic oesophagectomy for cancer. METHODS: From a prospective single-institution database, 118 1-year disease-free survivors having undergone a R0 transthoracic oesophagectomy with gastric tubulization between 2000 and 2008 were identified retrospectively. BMI values were collected at the onset of the disease (pre-treatment BMI), at the time of surgery (preoperative BMI), at postoperative 6 months and 1 year after oesophagectomy (1-year BMI). Logistic regression was performed with adjustment for confounders to estimate odds ratios of the factors associated with a 1-year weight loss (WL) of at least 15% of the pre-treatment body weight (BW). RESULTS: At the onset of the disease, 5 patients (4%) were underweighted (BMI < 8.5 kg/m&sup2;), 65 (55%) were normal (BMI = 18.5-24.9 kg/m&sup2;), 36 (31%) were overweighted (BMI > 25 kg/m&sup2;) and 12 (10%) were obese (BMI > 30 kg/m&sup2;). Mean pre-treatment, preoperative, postoperative 6-month and 1-year BMI values were 24.64 ± 4 kg/m&sup2;, 23.55 ± 3.8 kg/m&sup2;, 21.7 ± 3 kg/m&sup2; and 21.97 ± 4 kg/m&sup2;, respectively. One-year WL ≥ 15% of the pre-treatment BW was present in 29 patients (25%): 18 among the 48 patients (37%) with a pre-treatment BMI ≥ 25 and 11 among the 70 patients (15%) with pre-treatment BMI < 25 (P = 0.006). On logistic regression, initial overweighting was the sole independent prognosticator of 1-year postoperative WL of at least 15% of the pre-treatment BW (P = 0.039; OR: 2.96, [1.06-8.32]). CONCLUSIONS: Postoperative malnutrition remains a severe problem after oesophageal cancer resection, even in long-term disease-free survivors. Overweight and obese patients are the segment population most exposed to this postoperative malnutrition, suggesting that such surgery could have substantial bariatric effect. A special vigilance programme on the nutritional status of this sub-group of patients should be the rule.
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