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  • Title: A positive wave at 8 ms (P8) and modified auditory brainstem responses measurement in auditory neuropathy spectrum disorder.
    Author: Schmidt CM, Huebner JR, Deuster D, Zehnhoff-Dinnesen AA, Knief A.
    Journal: Int J Pediatr Otorhinolaryngol; 2012 May; 76(5):636-41. PubMed ID: 22336173.
    Abstract:
    OBJECTIVE: Auditory neuropathy spectrum disorder (ANSD) is characterized by absent or atypical auditory brainstem responses (ABR), recordable otoacoustic emissions and/or cochlear microphonics. Modification of ABR stimuli is discussed to improve wave V synchronization in ANSD patients. DESIGN: Ten ANSD children (seven unilateral) underwent ABR measurement with an alternating stimulus (40.5s(-1)), constant rarefaction and condensation stimuli, a reduced click-rate (11.1s(-1)) and a chirp-stimulus. RESULTS: The results showed no remarkably better synchronization with modified stimuli. Whereas higher levels showed no synchronization, reproducible positive waves at 8 ms (P8) at intensities of 65-85 dB were found in six patients with all stimuli. CONCLUSIONS: We suggest an ipsilateral auditory origin of the positive potentials at 8 ms. They could be characteristic of synchronization abnormalities in some cases of ANSD.
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