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  • Title: [Localization of the structural gene for botulinum neurotoxin type A using synthetic DNA probe for neurotoxin light chain].
    Author: Stepanova MV, Bystrov NS, Severtsova NV, Korobko VG, Bulatova TI, Zubova TM, Evstigneev VI, Smirnov EV, Vertiev IuV.
    Journal: Mol Gen Mikrobiol Virusol; 1990 Jun; (6):11-4. PubMed ID: 2233779.
    Abstract:
    To obtain the information on the genetic control of toxin production in the botulism causative agents, the oligonucleotides were synthesized as the molecular probes by translation of the amino acid sequence of the botulinic type A neurotoxin. The optimal conditions for hybridization of botulinic DNA with the synthetic DNA probes were determined and the probes specificity was demonstrated. The DNA fragments homologous to the probes used were shown to belong to bacterial genome, but not to bacteriophage one.
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