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  • Title: [Leukocyte migration inhibition test in celiac disease].
    Author: Horváth K, Horn G, Walcz E, Zavodni I, Bodánszky H.
    Journal: Orv Hetil; 1990 Nov 11; 131(45):2471-4. PubMed ID: 2234940.
    Abstract:
    The leukocyte migration inhibition test is a method used to assess the cell-mediated immune function. The authors examined 251 samples for a period of 3 years; 169 samples from celiac patients and 82 were control. The sensitivity of this test was 34/35 (97%) in proved gluten sensitive patients, but this was found after repeating the test at different periods of time. According to these results the authors conclude that the efficacy of this test is less sensitive in the newly diagnosed celiac patients, which means that it is not suitable for screening purpose, but useful for detecting gliadin sensitivity during the diagnostic period of celiac disease (e. i. the 3 biopsies). LMT may be used to indicate the proper time for the 2nd and/or 3rd biopsy, and can also be used to reveal the gluten-free diet defaults. The authors agree with those who believe that this test cannot substitute the performance of the small intestinal biopsy.
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