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  • Title: Growth failure, somatomedin and growth hormone levels in juvenile diabetes mellitus--a pilot study.
    Author: Nash H.
    Journal: Aust N Z J Med; 1979 Jun; 9(3):245-9. PubMed ID: 223535.
    Abstract:
    Growth hormone (hGH) responsiveness to exercise and somatomedin C (SmC) activity were measured in ten children with insulin-deficient diabetes mellitus. Four of the ten children showed a significant degree of growth retardation. Normal SmC activity was found in association with elevated hGH levels. The hypothesis that growth-retarded diabetics have a failure of Sm production despite high hGH levels (analogous to malnutrition and Laron dwarfism) was not substantiated by this study. Chronic deficiency of insulin, itself a somatomedin, may play a major role in diabetic growth failure.
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