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  • Title: Comparison of personality characteristics in Parkinson disease patients with and without impulse control disorders and in healthy volunteers.
    Author: Farnikova K, Obereigneru R, Kanovsky P, Prasko J.
    Journal: Cogn Behav Neurol; 2012 Mar; 25(1):25-33. PubMed ID: 22353727.
    Abstract:
    OBJECTIVE: We aimed to assess personality characteristics in patients with Parkinson disease (PD) with and without impulse control disorders (ICD). METHODS: We tested patients and controls with the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) scales that have expected high sensitivity to apparent addictive behavior. We recorded mean disease duration and mean levodopa dose in the PD groups. RESULTS: Of the 46 PD patients, 13 had ICD: hypersexuality, binge eating, or dopamine dysregulation. The PD patients with ICD had a longer duration of disease (11 vs. 5 y) and were taking higher doses of levodopa (900 vs. 500 mg/d). They scored above the pathologic threshold in 4 domains of the MMPI-2 Clinical Scales and in 8 Clinical Subscales and Content Scales. The most significant abnormality was Alienation-Self and Others. CONCLUSIONS: ICDs in the general population have similarities to disorders of substance addiction. In PD patients, some personality profiles could play a role in development of ICDs or dopamine dysregulation syndrome. The MMPI-2 may be a useful test for PD patients in general, and for detecting ICD in particular.
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