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  • Title: Correlation of splenectomy with portal vein thrombosis in beta-thalassemia major.
    Author: Hassan MN, Tahereb GM, Ahmad T, Asghar DA, Reza ED, Ali B, Mohsen MN.
    Journal: J Pak Med Assoc; 2011 Aug; 61(8):760-2. PubMed ID: 22355997.
    Abstract:
    OBJECTIVE: To evaluate the correlation of portal vein thrombosis and splenectomy in beta-thalassemia major patients visiting Babol Medical University, Iran. METHODS: This cohort study was done from 1997 to 2008. In our study, major beta-thalassemic patients visiting for transfusion at least once a month at Amirkola Children's Hospital were selected. Portal vein thrombosis was diagnosed through Doppler ultrasound in symptomatic patients. Cases were 160 beta-thalassemia major patients who underwent splenectomy and 160 remaining thalassemic patients without splenectomy were controls. Statistical comparison with Fisher exact test was performed. RESULTS: Five cases had suffered from portal vein thrombosis (P = 0.03). Majority patients with portal vein thrombosis had their symptoms after first month of the operation. CONCLUSION: Correlation of splenectomy with portal vein thrombosis is statistically significant among beta-thalassemic children from Iran.
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