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  • Title: Build/couple/pair strategy combining the Petasis 3-component reaction with Ru-catalyzed ring-closing metathesis and isomerization.
    Author: Ascic E, Le Quement ST, Ishoey M, Daugaard M, Nielsen TE.
    Journal: ACS Comb Sci; 2012 Apr 09; 14(4):253-7. PubMed ID: 22356899.
    Abstract:
    A "build/couple/pair" pathway for the systematic synthesis of structurally diverse small molecules is presented. The Petasis 3-component reaction was used to synthesize anti-amino alcohols displaying pairwise reactive combinations of alkene moieties. Upon treatment with a ruthenium alkylidene-catalyst, these dienes selectively underwent ring-closing metathesis reactions to form 5- and 7-membered heterocycles and cyclic aminals via a tandem isomerization/N-alkyliminium cyclization sequence.
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