These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: CD4/CD8 dual-positive mycosis fungoides: a previously unrecognized variant.
    Author: Knapp CF, Mathew R, Messina JL, Lien MH.
    Journal: Am J Dermatopathol; 2012 May; 34(3):e37-9. PubMed ID: 22356917.
    Abstract:
    Mycosis fungoides (MF) is a primary cutaneous lymphoma characterized by atypical T-lymphocytes that usually presents as patches and plaques on photoprotected areas of the body, such as the groin and buttocks. Classically, the atypical lymphocytes in MF are CD3/CD4 positive with loss of CD7 and less often loss of CD5. In a minority of cases, the atypical infiltrate is CD8 positive. We report a case of biopsy-proven MF in an elderly woman who presented with sclerodermoid lesions on her abdomen and thigh. Immunohistochemical studies revealed coexpression of CD4 and CD8 in a subset of atypical T-lymphocytes, and this was confirmed with flow cytometry. To our knowledge, this is the first report of a CD4/CD8 dual-positive MF.
    [Abstract] [Full Text] [Related] [New Search]