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  • Title: Effect of ACTH on the relaxation of guinea pig trachea with various bronchodilators.
    Author: Kitamura S, Ishihara Y, Kosaka K, Fukushima Y.
    Journal: Arzneimittelforschung; 1978; 28(8):1389-91. PubMed ID: 223581.
    Abstract:
    The effect of ACTH on the actions of various bronchodilators was examined using the isolated guinea pig tracheal smooth muscle. Relaxing effects of isolated guinea pig tracheal smooth muscle with 1-isoproterenol hydrochloride, salbutamol hemisulfate, hexoprenaline hydrochloride and epinephrine except prostaglandin E2 and aminophylline were markedly potentiated by combining ACTH. These results may suggest that ACTH has a direct effect on guinea pig tracheal smooth muscle by potentiating the actions of various beta-receptor stimulators.
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