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  • Title: Probe sialidase substrate specificity using chemoenzymatically synthesized sialosides containing C9-modified sialic acid.
    Author: Khedri Z, Muthana MM, Li Y, Muthana SM, Yu H, Cao H, Chen X.
    Journal: Chem Commun (Camb); 2012 Apr 04; 48(27):3357-9. PubMed ID: 22361713.
    Abstract:
    A library of α2-3- and α2-6-linked sialyl galactosides containing C9-modified sialic acids was synthesized from C6-modified mannose derivatives using an efficient one-pot three-enzyme system. These sialosides were used in a high-throughput sialidase substrate specificity assay to elucidate the importance of C9-OH in sialidase recognition.
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