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  • Title: The cytotoxic principles of Pseudolarix kaempferi: pseudolaric acid-A and -B and related derivatives.
    Author: Pan DJ, Li ZL, Hu CQ, Chen K, Chang JJ, Lee KH.
    Journal: Planta Med; 1990 Aug; 56(4):383-5. PubMed ID: 2236294.
    Abstract:
    Pseudolaric acid-A and -B, the novel diterpene acids isolated from Pseudolarix kaempferi, and their related derivatives have been tested for cytotoxicity against KB, A-549, HCT-8, P-388, and L-1210 tumor cells. The results showed that pseudolaric acid-A and -B demonstrated potent cytotoxicity. The selectivity of pseudolaric acid-A and -B which inhibit the growth of particular cell types within the disease-oriented human cancer cell line panels is discussed.
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