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  • Title: Immunomodulatory studies of a bioactive fraction from the fruit of Prunus cerasus in BALB/c mice.
    Author: Abid S, Khajuria A, Parvaiz Q, Sidiq T, Bhatia A, Singh S, Ahmad S, Randhawa MK, Satti NK, Dutt P.
    Journal: Int Immunopharmacol; 2012 Apr; 12(4):626-34. PubMed ID: 22366406.
    Abstract:
    In order to evaluate the role of ethyl acetate fraction (PNRS-EtOAC) obtained from the Prunus cerasus fruit in the modulation of immune responses, detailed studies were carried out using a panel of in vivo assays. Oral administration of PNRS-EtOAC (25-100 mg/kg) stimulated the IgM and IgG titre expressed in the form of hemagglutination antibody (HA) titre. Further, it elicited a dose related increase in the delayed type hypersensitivity reaction (DTH) after 24 and 48 h in BALB/c mice. Besides augmenting the humoral and cell mediated immune response, the concentration of cytokines (IFN-γ, IL-4, and TNF-α) in serum with respect to T cell interactions, i.e. the proliferation of lymphocytes were significantly increased at 50 mg/kg compared with the control. The results in these studies demonstrated the immunostimulatory effect of PNRS-EtOAC in a dose-dependent manner with respect to the macrophage activation possibly expressing the phagocytosis and nitrite production by the enhancement of TNF-α production as a mode of action.
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