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  • Title: Discovery of GS-9451: an acid inhibitor of the hepatitis C virus NS3/4A protease.
    Author: Sheng XC, Appleby T, Butler T, Cai R, Chen X, Cho A, Clarke MO, Cottell J, Delaney WE, Doerffler E, Link J, Ji M, Pakdaman R, Pyun HJ, Wu Q, Xu J, Kim CU.
    Journal: Bioorg Med Chem Lett; 2012 Apr 01; 22(7):2629-34. PubMed ID: 22366653.
    Abstract:
    The discovery of GS-9451 is reported. Modification of the P3 cap and P2 quinoline with a series of solubilizing groups led to the identification of potent HCV NS3 protease inhibitors with greatly improved pharmacokinetic properties in rats, dogs and monkeys.
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