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  • Title: From HLA association to function.
    Author: Barrett JC.
    Journal: Nat Genet; 2012 Feb 27; 44(3):235-6. PubMed ID: 22366857.
    Abstract:
    A new study refines the association signals for rheumatoid arthritis susceptibility in the major histocompatibility complex (MHC) region to five amino-acid positions encoded in three HLA genes, all within peptide-binding grooves. By adapting statistical methods from genome-wide association studies (GWAS) and using imputation from a large reference panel, they demonstrate the potential for this approach to identify functional variants in associated regions.
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