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  • Title: Selective alkylation of (hetero)aromatic amines with alcohols catalyzed by a ruthenium pincer complex.
    Author: Agrawal S, Lenormand M, Martín-Matute B.
    Journal: Org Lett; 2012 Mar 16; 14(6):1456-9. PubMed ID: 22369039.
    Abstract:
    A readily available pincer ruthenium(II) complex catalyzes the selective monoalkylation of (hetero)aromatic amines with a wide range of primary alcohols (including pyridine-, furan-, and thiophene-substituted alcohols) with high efficiency when used in low catalyst loadings (1 mol %). Tertiary amine formation via polyalkylation does not occur, making this ruthenium system an excellent catalyst for the synthesis of sec-amines.
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