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  • Title: [Effect of PTH on bone structural properties].
    Author: Ito M.
    Journal: Clin Calcium; 2012 Mar; 22(3):335-41. PubMed ID: 22370300.
    Abstract:
    Once-daily administration of parathyroid hormone (PTH) causes increased bone formation and bone mass. Both the anabolic and resorptive actions can be considered in the context of the anabolic window, a period of time during which PTH affects bone formation to a greater extent than it stimulates bone resorption. PTH appears to increase bone strength by increasing bone volume, number and connectivity of bone trabeculae, as well as by transformation from rod-like structure to plate-like structure. The change of cortical bone strength is complicated due to the increase of cortical thickness associated with increase in cortical porosity. The combination and sequential therapies with anti-resorptive agents are investigating from the view point of the effect of bone quality and bone strength.
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