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  • Title: Recombinant activated factor VII for hemorrhage after pediatric cardiac surgery.
    Author: Singh SP, Chauhan S, Choudhary M, Vasdev S, Talwar S.
    Journal: Asian Cardiovasc Thorac Ann; 2012 Feb; 20(1):19-23. PubMed ID: 22371937.
    Abstract:
    Postoperative bleeding is a common complication after pediatric cardiac surgery. Use of recombinant activated factor VII for intractable hemorrhage after cardiac, pediatric, and neurosurgery has been shown to decrease postoperative bleeding, but data in children are limited. This retrospective study analyzed 20 children <15 years-old who underwent cardiac surgery and received recombinant activated factor VII for refractory postoperative hemorrhage. All patients underwent mediastinal reexploration before recombinant activated factor VII was administered as a bolus dose over 2-3 min as rescue therapy. If no significant decrease in chest tube drainage was observed, the dose was repeated after an interval of at least 2 h. The median dose of recombinant activated factor VII administered per bleeding episode was 83.33 μg·kg(-1) (range, 72.47-87.50 μg·kg(-1)), and the dose per patient was 154.16 μg·kg(-1) (range, 93.06-180.52 μg·kg(-1)). The median number of doses found to be effective in these children was 1.76. There were significant decreases in mediastinal chest tube drainage and the volume of packed red blood cells, platelet concentrates, and cryoprecipitate administered after recombinant activated factor VII. No complications were observed during the therapy.
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