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  • Title: DNA-directed three-dimensional protein organization.
    Author: Zhang C, Tian C, Guo F, Liu Z, Jiang W, Mao C.
    Journal: Angew Chem Int Ed Engl; 2012 Apr 02; 51(14):3382-5. PubMed ID: 22374892.
    Abstract:
    All bound together: self-assembled symmetric DNA polyhedra were used to organize proteins in 3D space. Biotin moieties were incorporated into the self-assembled symmetric DNA polyhedra. Upon incubation with streptavidin (STV) protein, an STV protein became bound to each polyhedral face, thus resulting in well-structured DNA polyhedra/STV complexes. This strategy was also applied to different 3D DNA nanostructures and different proteins.
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