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  • Title: [Retrobulbar irradiation of endocrine ophthalmopathy: a comparison between 10 and 16 Gy total dose].
    Author: Pfluger T, Wendt T, Toroutoglou N, Pickardt C, Wuttge R.
    Journal: Strahlenther Onkol; 1990 Oct; 166(10):673-7. PubMed ID: 2237752.
    Abstract:
    Severe Graves' ophthalmopathy has been treated in 44 cases by orbital irradiation. 36 out of 37 patients showed a good response or a suspend of the progressive disease. In 17 out of 33 primary irradiations a dose of 10 Gy and in 16 cases a dose of 16 Gy was applied. Measured by ophthalmopathy-index significant better results have been achieved by a total dose of 16 Gy. Because of recurrence after primary irradiation of 10 Gy a re-irradiation became necessary in 35% of the cases. Primary irradiation of 16 Gy has required no further treatment during the same time of observation. A single series of 16 Gy irradiation has shown better results than two series of 10 Gy irradiation concerning the proptosis and alleviation of symptoms.
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