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  • Title: Remarkably high rate of DNA amplification promoted by the mating-type switching mechanism in Schizosaccharomyces pombe.
    Author: Yu C, Bonaduce MJ, Klar AJ.
    Journal: Genetics; 2012 May; 191(1):285-9. PubMed ID: 22377633.
    Abstract:
    A novel mating-type switching-defective mutant showed a highly unstable rearrangement at the mating-type locus (mat1) in fission yeast. The mutation resulted from local amplification of a 134-bp DNA fragment by the mat1-switching phenomenon. We speculate that the rolling-circle-like replication and homologous recombination might be the general mechanisms for local genome region expansion.
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