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  • Title: Agranulocytosis during treatment of chronic hepatitis C complicated by hyperthyreosis. Case reports.
    Author: Kozielewicz D, Karwowska K, Dybowska D, Halota W.
    Journal: Endokrynol Pol; 2012; 63(1):52-5. PubMed ID: 22378098.
    Abstract:
    Agranulocytosis is a life-threatening disorder characterised by a greatly decreased number of circulating neutrophils below 500/μL. This article presents two cases of agranulocytosis in patients treated with pegylated interferon and ribavirin due to chronic hepatitis C. Interferon induced hyperthyroidism, which required the use of a tyreostatic. Anti-thyroid drugs (ATD) used to treat hyperthyroidism can cause agranulocytosis. The synergistic reaction of ATD and interferon on bone marrow cannot be excluded.
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