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  • Title: Factors associated with caregivers' underestimation of quality of life in patients with Alzheimer's disease.
    Author: Zhao H, Novella JL, Dramé M, Mahmoudi R, Barbe C, di Pollina L, Aquino JP, Pfitzenmeyer P, Rouaud O, George MY, Ankri J, Blanchard F, Jolly D.
    Journal: Dement Geriatr Cogn Disord; 2012; 33(1):11-7. PubMed ID: 22378499.
    Abstract:
    OBJECTIVE: The aim of this study was to identify the factors associated with differences between how Alzheimer's disease (AD) patients and their caregivers rate the patient's health-related quality of life (QoL). METHODS: Cross-sectional, multicentre study. Patients were 65 years or more, suffering from mild to moderate AD, native French speakers, with a main caregiver. Interrater agreement of the QoL-AD was assessed using the intraclass coefficient. A generalised linear model was used to identify factors related to the difference in health-related QoL scores between patients and their caregivers. RESULTS: The 122 patients of the study were 82 ± 6 years old and mainly women (69%). Independent factors related to the difference between patients and caregivers were: Mini Mental State Exam score (β = 0.32; 95% CI = 0.05-0.59); instrumental activities of daily living score (β = -0.61; 95% CI = -1.14 to -0.07); total Neuropsychiatric Inventory score (β = 0.10; 95% CI = 0.05-0.59), and Zarit's burden score (β = 0.09; 95% CI = 0.01-0.17). CONCLUSION: Practitioners must take into account the trend towards underestimation when health-related QoL is rated by caregivers or proxies.
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