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  • Title: Role of 5-hydroxytryptamine2C receptors in marble-burying behavior in mice.
    Author: Egashira N, Okuno R, Shirakawa A, Nagao M, Mishima K, Iwasaki K, Oishi R, Fujiwara M.
    Journal: Biol Pharm Bull; 2012; 35(3):376-9. PubMed ID: 22382324.
    Abstract:
    We examined the role of 5-hydroxytryptamine(2C) (5-HT(2C)) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT(2C) agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT(2C) antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAY161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT(2C) receptors play a role in marble-burying behavior in mice.
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