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  • Title: Antidiarrhetic loperamide hydrochloride.
    Author: Brüning J, Podgorski D, Alig E, Bats JW, Schmidt MU.
    Journal: Acta Crystallogr C; 2012 Mar; 68(Pt 3):o111-3. PubMed ID: 22382543.
    Abstract:
    Single crystals of the anhydrous form of the title compound {systematic name: 1-[3-(dimethylcarbamoyl)-3,3-diphenylpropyl]-4-hydroxy-4-(4-chlorophenyl)piperidin-1-ium chloride}, C(29)H(34)ClN(2)O(2)(+)·Cl(-), were obtained by diffusion of acetone into a solution in 2-propanol. In the structure, N-H...Cl(-) and O-H...Cl(-) hydrogen bonds connect neighbouring molecules and chloride anions to form chains along the c-axis direction. Neighbouring chains along the b-axis direction are connected by intermolecular C-H...Cl(-) contacts, defining layers parallel to the (100) planes. The layers are connected by weak intermolecular C-H...Cl interactions only, which may account for the plate-like shape of the crystals.
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