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  • Title: The structure of glibenclamide in the solid state.
    Author: Sanz D, Claramunt RM, Alkorta I, Sánchez-Sanz G, Elguero J.
    Journal: Magn Reson Chem; 2012 Mar; 50(3):246-55. PubMed ID: 22383432.
    Abstract:
    The structure of glibenclamide, 5-chloro-N-(2-{4-[(cyclohexylamino)carbonyl] aminosulfonyl}phenyl) ethyl)-2-methoxybenzamide, an important antidiabetic drug, has been studied both in solution and in the solid state by a combination of NMR spectroscopy and theoretical calculations. The possibility that glibenclamide suffers a tautomerization under melting to afford a desmotrope was rejected.
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