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  • Title: Relationship between serum interleukin-1beta levels and acute phase response proteins in patients with familial Mediterranean fever.
    Author: Yildirim K, Uzkeser H, Keles M, Karatay S, Kiziltunc A, Kaya MD, Yildirim A.
    Journal: Biochem Med (Zagreb); 2012; 22(1):109-13. PubMed ID: 22384525.
    Abstract:
    INTRODUCTION: The aim of this study was to investigate whether serum levels of interleukin-1beta (IL-1beta) has any possible correlation on inflammatory parameters such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and fibrinogen concentration in patients with familial Mediterranean fever (FMF) patients during attack-free period. MATERIALS AND METHODS: The serum levels of IL-1beta, as an indicator of cytokines status, and the acute phase response proteins, CRP, ESR and fibrinogen levels were evaluated in 35 attack-free patients with FMF and 25 healthy volunteers. RESULTS: Serum IL-1beta levels were significantly higher in patients with FMF than control subjects (P = 0.018). There was no statistically significant difference in the serum levels of ESR, CRP and fibrinogen between two groups (P = 0.181, P = 0.816, P = 0.686, respectively). There was a significant correlation between IL-1beta and CRP (r = 0.513, P = 0.002) values of FMF group. CONCLUSIONS: In conclusion, our results confirm the presence of increased IL-1beta levels in FMF patients during attack-free period. Serum IL-1beta values seems to correlate with CRP levels. The elevation of IL-1beta levels may be important in monitoring subclinical inflammation of attack free period in FMF patients. UVOD:: Cilj ovog istraživanja je ispitati postoji li korelacija između koncentracije interleukina-1β (IL-1β) s upalnim parametrima kao što su C-reaktivni protein (CRP) i brzina sedimentacije eritrocita (engl. erythrocyte sedimentation rate, ESR) te koncentracijom fibrinogena kod bolesnika oboljelih od obiteljske mediteranske groznice (engl. familial Mediterranean fever, FMF). MATERIJALI I METODE:: Koncentracija IL-1β u serumu, kao indikator statusa citokina, i odgovor proteinske akutne faze, ESR te koncentracije CRP i fibrinogena određene su kod bolesnika s FMF bez napada i kod 25 zdravih ispitanika. REZULTATI:: Kod bolesnika s FMF je koncentracija IL-1β u serumu bila značajno viša nego kod kontrolnih ispitanika (P = 0,018). Nije bilo statistički značajne razlike u brzini ESR te koncentraciji CRP i fibrinogena u serumu između skupina (P = 0,181 za ESR, P = 0,816 za CRP, P = 0,686 za fibrinogen). Dobivena je značajna korelacija između koncentracija IL-1β i CRP (r = 0,513, P = 0,002) u serumu u skupini bolesnika s FMF. ZAKLJUČAK:: Naši rezultati potvrđuju postojanje povišene koncentracije IL-1β u serumu kod bolesnika s FMF tijekom razdoblja u kojem bolesnici nemaju napade. Povišenje koncentracije IL-1β moglo bi biti značajno kod promatranja prikrivenih (subkliničkih) oblika upale u razdoblju u kojem bolesnici oboljeli od FMF nemaju napade.
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