These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synthesis of imidazo[4,5-c]pyrazoles via copper-catalyzed amidine cyclization.
    Author: Liubchak K, Tolmachev A, Nazarenko K.
    Journal: J Org Chem; 2012 Apr 06; 77(7):3365-72. PubMed ID: 22385015.
    Abstract:
    A new synthetic approach to 4-substituted imidazo[4,5-c]pyrazoles is proposed on the basis of the N'-(4-halopyrazol-5-yl)amidine cyclization under the conditions of copper-catalyzed cross-coupling reactions. Using 5-aminopyrazoles and copper catalysts as starting materials, the method is inexpensive and convenient and allows a wide range of substituents at all positions of the imidazo[4,5-c]pyrazole nucleus.
    [Abstract] [Full Text] [Related] [New Search]