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  • Title: [Various characteristics of protein-synthesizing apparatus of the myocardium during total ischemia].
    Author: Maskoliunas RK, Lekis AV, Kovalenko MI, El'skaia AV, Lukoshiavichius LIu.
    Journal: Vopr Med Khim; 1990; 36(4):7-10. PubMed ID: 2238536.
    Abstract:
    A decrease in the rate of protein synthesis as well as an increase in the synthesis time of "medium-size" polypeptide chain were detected in total rabbit myocardium ischemia, which were evaluated using rabbit myocardium cell-free protein-synthesizing systems. The decrease in the synthesis rate of total myocardial proteins was shown to depend on the state of ribosomes function. Redistribution in the pools of membrane-bound and free ribosomes as well as a decrease of polyribosomes amount in total pool of myocardial ribosomes were observed under conditions of total myocardial ischemia.
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