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  • Title: Increase in Na+, K+ -ATPase enzyme units in liver and kidneys from essential fatty acid deficient rats.
    Author: Lin MH, Romsos DR, Akera T, Leveille GA.
    Journal: Experientia; 1979 Jun 15; 35(6):735-6. PubMed ID: 223871.
    Abstract:
    (3H)-Ouabain binding to liver and kidney preparations was utilized to estimate the number of Na+, K+-ATPase enzyme units in livers and kidneys from rats fed 2% corn oil supplemented or fat-free diets. The specific (3H)-ouabain binding in liver and kidney preparations from fatty acid deficient rats was increased approximately 40%, but the affinity of the binding sites for ouabain (Kd-value) remained unchanged. The increased concentration of Na+, K+-ATPase enzyme units observed in the essential fatty acid deficient rats may contribute to the reduced body fat accumulation and elevated heat production observed in these animals.
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