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  • Title: The composition of the culture medium influences the β-1,3-glucan metabolism of Aspergillus fumigatus and the antifungal activity of inhibitors of β-1,3-glucan synthesis.
    Author: Clavaud C, Beauvais A, Barbin L, Munier-Lehmann H, Latgé JP.
    Journal: Antimicrob Agents Chemother; 2012 Jun; 56(6):3428-31. PubMed ID: 22391552.
    Abstract:
    In vitro testing of Aspergillus fumigatus susceptibility to echinocandins has always been a challenge. Using a simple and quick colorimetric method to analyze the activity of inhibitors of β-1,3-glucan synthesis, we found that the composition of the culture medium significantly influences glucan synthesis and consequently the antifungal properties of inhibitors of β-1,3-glucan synthesis when they are tested alone or in combination with chitin synthase inhibitors.
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