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  • Title: Short-term cefotaxime prophylaxis reduces the failure rate in lower limb amputations.
    Author: Norlin R, Frydén A, Nilsson L, Anséhn S.
    Journal: Acta Orthop Scand; 1990 Oct; 61(5):460-2. PubMed ID: 2239174.
    Abstract:
    The effect of prophylaxis with a broad-spectrum antibiotic agent in lower limb amputations was studied in a prospective, randomized investigation of 38 patients. Nineteen received cefotaxime (Claforan) and 19 served as controls. Three patients died in the immediate post-operative period. In the treatment group, 15/18 healed compared with 10/17 controls (P less than 0.001). We concluded that short-term cefotaxime prophylaxis increases the chances to achieve good stump healing.
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