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  • Title: [Analysis of SYT/SSX1 and SYT/SSX2 fusion genes from synovial sarcoma].
    Author: Kekeeva TV, Riazantseva AA, Zavalishina LÉ, Andreeva IuIu, Babenko OV, Zaletaev DV, Frank GA.
    Journal: Mol Biol (Mosk); 2011; 45(5):840-4. PubMed ID: 22393780.
    Abstract:
    The t(X;18)(p11;q11) translocation has been shown to be the specific alteration for synovial sarcomas. The translocation leads to production of chimeric protein SYT/SSX by fusion of SYT and SSX genes involved. The expression analysis of SYT/SSX1 and SYT/SSX2 chimeric transcripts was performed in formalin-fixed soft tissue tumour specimens and the diagnostic validity of immunohistochemistry, FISH and RT-PCR methods was compared. The chimeric transcripts were detected in 12 from 16 synovial sarcomas: 7 SYT/SSX1 and 5 SYT/SSX2 fusion variants; by fluorescence hybridization in situ (FISH) the translocation was found in 13 from 16 sarcoma samples. As synovial sarcoma represents a diagnostically challenging group, genetic analysis of translocations and chimeric transcripts is an extremely useful confirmatory diagnostic tool providing higher sensitivity than immunohistochemistry markers do.
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