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  • Title: [Effects and mechanisms of autophagy of trophoblast cells in severe preeclampsia].
    Author: Chen GQ, Zhang H, Qi HB, Yao ZW, Gao L, Qiu CL.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2012 Mar; 28(3):294-6. PubMed ID: 22394641.
    Abstract:
    AIM: To investigate the occurrence law of autophagy in trophoblast cells from severe preeclampsia and its possible mechanisms of wrecking cells. METHODS: 23 cases of placenta tissues were collected from women suffer from severe preeclampsia and normal pregnant women respectively. Surface villous of placental was observed by scanning electron microscope, and ultrastructure and autophagosome of trophoblast cells were observed by transmission electron microscopic. The expressions of Beclin-1 and LC3II in placenta tissues were detected by Immunohistochemical technique, then its relevance whit weight of fetus and placental was analyzed. RESULTS: Compared with the control group, villous were decrease in placenta tissue from patients suffer from severe preeclampsia, and its arrangement was disordered; typical autophagosomes of trophoblast cells were observed by transmission electron microscope. The expression of Beclin-1, LC3IIwere significantly up-regulated in placenta tissue from patients suffer from severe preeclampsia.The correlation coefficient of Beclin-1, LC3II and placental weight, fetal weight respectively were -0.977, -0.930, -0.812, -0.849. CONCLUSION: Autophagy were significantly up-regulated in trophoblast cells from patients suffer from severe preeclampsia by increasing expression of Beclin-1, LC3II protein, and its expression was negatively related to weight of fetus and placental.
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