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  • Title: The involvement of TGF-β1 and CTGF in regional gingival overgrowth.
    Author: Niţulescu EA, Crăiţoiu MM, Baniţă MI, Drăghici E, Crăiţoiu Ş.
    Journal: Rom J Morphol Embryol; 2012; 53(1):143-50. PubMed ID: 22395513.
    Abstract:
    Gingival overgrowth is a multifactorial and invalidating condition. Our research is about gingival overgrowth caused by gingival plaque, its purpose being the evaluation of the presence of gingivitis and/or parodontitis in patients with gingival growth and the extent in which there is a connection between gingival overgrowth and the inflammatory process that can contribute to an exceedingly stimulation of the overgrowth. Immunohistological study was conducted on human material--gingival mucosa that came from patients with ages between 20-65 years, divided into three groups: group I--control group, group II--patients with gingivitis, group III--patients with local or general periodontitis. The intensity of immunohistochemical staining of TGF-β1 and CTGF varies from one group to another, and also depends on the area of gingival mucosa that was observed. TGF-β1 has a crucial role in periodontal disease fibrogenesis by intensifying the action of CTGF.
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