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  • Title: Studies on the mechanism of macrophage aggregation induced by lymphokines.
    Author: Badenoch-Jones P, Rouveix B, Turk JL.
    Journal: Immunology; 1979 Jun; 37(2):361-6. PubMed ID: 223977.
    Abstract:
    Macrophage aggregation (measured by a light-scattering technique) induced by unpurified lymphokine preparations has been investigated. This has been shown to be Ca2+ or Mg2+ dependent and to be inhibited by a number of agents known to affect cellular physiology and biochemistry. The divalent cation ionophore A23187 causes a macrophage aggregation superficially similar to that induced by lymphokines, although differences were found. It is suggested that a biochemical response by the macrophage is required for aggregation induced by lymphokines, and thus measurements of macrophage aggregation allow a study of the early events in the response of macrophages to lymphokines.
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