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  • Title: Fibrillary glomerulonephritis presenting as rapidly progressive glomerulonephritis.
    Author: Sharma P, Kuperman M, Racusen L, Geetha D.
    Journal: Am J Kidney Dis; 2012 Jul; 60(1):157-9. PubMed ID: 22398109.
    Abstract:
    Fibrillary glomerulonephritis (GN) is an uncommon cause of rapidly progressive kidney failure. We report a case of rapidly progressive kidney failure with kidney biopsy showing crescentic GN on light microscopy and immunofluorescence showing linear/globular glomerular basement membrane (GBM) staining for immunoglobulin G and C3, consistent with anti-GBM disease. However, electron microscopy showed fibrillary deposits in the GBM, suggesting a diagnosis of fibrillary GN. As exemplified by this case, it is important to consider fibrillary GN in the differential diagnosis of crescentic GN with linear immunoglobulin G deposits within the GBM. Electron microscopy is crucial to make this diagnosis.
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