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  • Title: Application of nanosized MCM-41 to fabrication of a nanostructured electrochemical sensor for the simultaneous determination of levodopa and carbidopa.
    Author: Mazloum-Ardakani M, Sheikh-Mohseni MA, Abdollahi-Alibeik M, Benvidi A.
    Journal: Analyst; 2012 Apr 21; 137(8):1950-5. PubMed ID: 22398429.
    Abstract:
    A novel carbon paste electrode modified with nanosized mesoporous MCM-41 was prepared, and used as an electrochemical sensor to study the electro oxidation of levodopa (LD), carbidopa (CD) and their mixtures. Using differential pulse voltammetry (DPV), a highly selective and simultaneous determination of LD and CD has been explored at the modified electrode. The electrochemical sensor displayed a good resolving function for the overlapping voltammetric responses of LD and CD into two separate peaks with a potential difference of 370 mV. DPV peak currents of LD increased linearly with concentration over the 0.13 μM to 1250.00 μM range and exhibited a detection limit of 0.072 μM. Also, the proposed electrochemical sensor was used for the determination of LD and CD in some real samples, using the standard addition method.
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