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  • Title: Association of abdominal aortic wall thickness in the newborn with maternal factors.
    Author: Iwashima S, Ishikawa T, Akira O, Itou H.
    Journal: Am J Perinatol; 2012 Jun; 29(6):441-8. PubMed ID: 22399211.
    Abstract:
    PURPOSE: The goal of the present study is to carry out prospective echocardiographic measurements of intima-media thickness (IMT) in the abdominal artery of newborns. METHODS: Study subjects were 96 mothers and their newborns. We measured the adjusted IMT (aIMT, mm/mm) of newborn abdominal arteries by high-resolution ultrasound and evaluated the association of aIMT with various maternal and newborn factors. RESULTS: Negative correlations were observed between aIMT and gestational age (r = - 0.678, p < 0.01) and positive correlations between aIMT and placenta-to-fetus weight ratio (r = 0.418, p < 0.01). Comparing the small-for-gestational-age (SGA) versus appropriate-for-gestational-age (AGA) categories, aIMT in the SGA (n = 14) was greater than in the AGA (n = 82), with values of [0.115 (0.117) mm/mm versus 0.084 (0.074) mm/mm, p < 0.01], respectively. A multiple linear regression analysis was performed with aIMT as a dependent variable, and significant correlations were noted with gestational age (R2 = 0.524, β = - 0.515, p < 0.001 for gestational age). CONCLUSION: On the basis of these findings, we suggest that aIMT thickness is associated with placenta-to-fetus weight ratio and gestational age, and that increased values of aIMT in SGA may indicate presence of a latent link to cardiovascular disease that might otherwise go undetected in infancy.
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