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  • Title: The measles virus N(TAIL)-XD complex: an illustrative example of fuzziness.
    Author: Longhi S.
    Journal: Adv Exp Med Biol; 2012; 725():126-41. PubMed ID: 22399322.
    Abstract:
    In this chapter, I focus on the biochemical and structural characterization of the complex between the intrinsically disordered C-terminal domain of the measles virus nucleoprotein (N(TAIL)) and the C-terminal X domain (XD) of the viral phosphoprotein (P). I summarize the main experimental data available so far pointing out the prevalently disordered nature of N(TAIL) even after complex formation and the role of the flexible C-terminal appendage in the binding reaction. I finally discuss the possible functional role of these residual disordered regions within the complex in terms of their ability to capture other regulatory, binding partners.
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