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  • Title: Primary oxalosis mimicking hyperparathyroidism diagnosed after long-term hemodialysis.
    Author: Canavese C, Salomone M, Massara C, Portigliatti Barbos M, Cadario A, Pavan I, Marangella M, Petrarulo M, Rotolo U.
    Journal: Am J Nephrol; 1990; 10(4):344-9. PubMed ID: 2240064.
    Abstract:
    Primary oxalosis is a rare inborn error of oxalate metabolism. Most cases are discovered in children, but occasionally symptoms begin later in life. Since early deaths in the past were from renal failure, prolonged survival obtained with chronic dialysis allows oxalosis to develop. This paper presents a 38-year-old man with an atypical history of type-I primary hyperoxaluria, not diagnosed until after 5 years of dialysis. Bone biopsy was performed because the biochemical and radiologic features did not seem consistent with a putative diagnosis of secondary hyperparathyroidism. This case emphasizes the clinical heterogeneity of this disorder, and the need for its considerations in the spectrum of dialysis-related bone diseases. It also stresses that bone oxalosis may mimic hyperparathyroidism, especially radiologically. Differential diagnosis is therefore mandatory.
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