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  • Title: Cholesterol localization in ultrathin frozen sections in Schnyder's corneal crystalline dystrophy.
    Author: Rodrigues MM, Kruth HS, Krachmer JH, Vrabec MP, Blanchette-Mackie J.
    Journal: Am J Ophthalmol; 1990 Nov 15; 110(5):513-7. PubMed ID: 2240137.
    Abstract:
    We examined a 57-year-old woman who had bilateral corneal crystalline deposits associated with xanthelasma. The patient's son had bilateral stromal haze. Plasma cholesterol and apolipoprotein A-I and B levels were normal. Histopathologic examination disclosed lipid deposits, particularly in the superficial stroma and Bowman's layer. These deposits stained with oil red O and filipin, a fluorescent probe that specifically detects unesterified cholesterol. Cryoultramicrotomy disclosed more specific ultrastructural localization of unesterified cholesterol with an array of crystals resembling multiple plates in extracellular corneal tissue.
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