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  • Title: Juvenile toxicity: are we asking the right questions?
    Author: Downes N.
    Journal: Toxicol Pathol; 2012 Jul; 40(5):830-7. PubMed ID: 22407308.
    Abstract:
    The recent increase in numbers of juvenile toxicity studies over the past few years has doubtless added to our knowledge of the development of organ systems in the young rodent, but it is perhaps rather more difficult to answer the questions as to whether this body of work has served us well in terms of assessing risk in the pediatric population. If there are shortcomings, are they the result of poor study design or poor sensitivity of the model, or are the wrong questions being posed? This article provides a superficial overview of the progress made thus far and considers which aspects of study design and model choice currently fail to adequately address the major issues surrounding pediatric toxicology.
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