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  • Title: A multicenter randomized placebo-controlled clinical trial of pramipexole for Tourette's syndrome.
    Author: Kurlan R, Crespi G, Coffey B, Mueller-Vahl K, Koval S, Wunderlich G, Pramipexole for TS Trial Investigators.
    Journal: Mov Disord; 2012 May; 27(6):775-8. PubMed ID: 22407510.
    Abstract:
    BACKGROUND: Dopamine agonists could theoretically normalize the suspected central dopamine hypersensitivity in Tourette's syndrome. METHODS: There was a multicenter randomized, placebo-controlled, double-blind clinical trial of pramipexole given for 6 weeks in 63 children and adolescents with Tourette's syndrome. RESULTS: There were no significant differences in the adjusted mean change in the Total Tic Score of the Yale Global Tic Severity Scale for patients treated with pramipexole (-7.16) and placebo (-7.17). There were no significant treatment effects on change from baseline in the Global Severity score of the Yale Scale and parent- and investigator-scored Clinical Global Impression of Improvement. In patients with attention deficit hyperactivity disorder, there was improvement in DuPaul ADHD scale scores for patients receiving pramipexole compared with placebo. CONCLUSIONS: There was no evidence that pramipexole has efficacy in suppressing tics. Pramipexole may decrease symptoms of associated attention deficit hyperactivity disorder.
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