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  • Title: ACTH, beta-LPH and beta-endorphin in pituitary adenomas of the patients with Cushing's disease: activation of beta-LPH conversion to beta-endorphin.
    Author: Suda T, Abe Y, Demura H, Demura R, Shizume K, Tamahashi N, Sasano N.
    Journal: J Clin Endocrinol Metab; 1979 Sep; 49(3):475-7. PubMed ID: 224076.
    Abstract:
    ACTH, beta-lipotropin (beta-LPH) and beta-endorphin concentrations were determined in pituitary adenomas of the patients with Cushing's disease. Immunoreactive ACTH and beta-endorphin were present in high concentrations and essentially equimolar amounts in pituitary adenomas. beta-LPH conversion to beta-endorphin was activated in pituitaries associated with ACTH/beta-LPH producing adenomas. Immunoreactive ACTH and beta-endorphin concentrations were markedly suppressed in the surrounding tissues.
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